Nexavar Fails Phase III NSCLC Trial

Bayer, Onyx drug shows no survival improvement in study

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By: Tim Wright

Editor-in-Chief, Contract Pharma

A Phase III trial evaluating Nexavar tablets in patients with advanced non-squamous non-small cell lung cancer (NSCLC) showed that the study did not meet its primary endpoint of improving overall survival in the first-line setting. The trial, called NExUS (NSCLC research Experience Utilizing Sorafenib), evaluated Nexavar versus placebo in combination with two chemotherapeutic agents, gemcitabine and cisplatin. A positive secondary endpoint of progression-free survival (PFS) was observed in the t...

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